{"id":68,"date":"2012-10-11T16:07:34","date_gmt":"2012-10-11T16:07:34","guid":{"rendered":"http:\/\/www.optflux.org\/?page_id=68"},"modified":"2015-12-18T14:33:38","modified_gmt":"2015-12-18T14:33:38","slug":"about-2","status":"publish","type":"page","link":"http:\/\/www.optflux.org\/?page_id=68","title":{"rendered":"About"},"content":{"rendered":"<p><strong>The OptFlux application includes a number of tools to support\u00a0<span style=\"color: #ff7800;\"><em>in silico<\/em>\u00a0metabolic engineering<\/span>. The application allows the user to load a genome-scale model of a given organism. This will serve as the basis to simulate the\u00a0<span style=\"color: #ff7800;\">wild type and mutants<\/span>\u00a0(original strain with a set of selected gene deletions).<\/strong><\/p>\n<p><strong>The simulation of these strains will be conducted using a number of approaches (e.g.\u00a0<span style=\"color: #ff7800;\">Flux-Balance Analysis, Minimization of Metabolic Adjustment or Regulatory On\/Off Minimization of metabolic fluxes<\/span>) that allow the set of fluxes in the organism&#8217;s metabolism to be determined, given a set of environmental constraints. The software also includes a number of optimization methods (e.g.\u00a0<span style=\"color: #ff7800;\">Evolutionary Algorithms or Simulated Annealing<\/span>) to reach the best set of gene deletions given an objective function, typically related with a given industrial goal. It also integrates visualization tools from the BioVisualizer application.<\/strong><\/p>\n<p><strong>The OptFlux application is being developed taking as a basis the\u00a0<span style=\"color: #ff7800;\">AIBench framework<\/span>. This is an environment for the development of Data Mining\/ Bioinformatics tools, using the Java programming language. The details of this project, a collaboration between the universities of Minho (Portugal) and Vigo (Spain), as well as updated documentation can be found at the web site.<\/strong><\/p>\n<h1>Acknowledgments<\/h1>\n<div>\n<p><img decoding=\"async\" src=\"wp-content\/uploads\/2015\/12\/COMPETE_Logo.jpg\" alt=\"\" \/><img decoding=\"async\" src=\"wp-content\/uploads\/2015\/12\/FCT_logo.jpg\" alt=\"\" \/><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The OptFlux application includes a number of tools to support\u00a0in silico\u00a0metabolic engineering. The application allows the user to load a genome-scale model of a given organism. This will serve as the basis to simulate the\u00a0wild type and mutants\u00a0(original strain with<span class=\"ellipsis\">&hellip;<\/span> <a href=\"http:\/\/www.optflux.org\/?page_id=68\"><\/p>\n<div class=\"see-more\">See more &#8250;<\/div>\n<p><!-- end of .see-more --><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.optflux.org\/index.php?rest_route=\/wp\/v2\/pages\/68"}],"collection":[{"href":"http:\/\/www.optflux.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.optflux.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.optflux.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.optflux.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=68"}],"version-history":[{"count":4,"href":"http:\/\/www.optflux.org\/index.php?rest_route=\/wp\/v2\/pages\/68\/revisions"}],"predecessor-version":[{"id":145,"href":"http:\/\/www.optflux.org\/index.php?rest_route=\/wp\/v2\/pages\/68\/revisions\/145"}],"wp:attachment":[{"href":"http:\/\/www.optflux.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=68"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}