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The model simplification operation requires at least one of the two datatypes:

Zero Value Fluxes - that can be obtained following a structural analysis or performing FVA.
Equivalent fluxes.



To simplify a model access the File -> Model Simplification menu:

SimplificationMENU.png

After this just select the project name, and which datatypes you want to use in the simplification (at least one of them is mandatory).

SimplifGUI.png

And that's it! Press OK and a new project will be added to the clipboard!

SimpliClip.png